For the majority of the nineteenth century, prescription drugs weren't remarkably powerful, primary Oliver Wendell Holmes Sr. to famously comment in 1842 that "if all medicines on the globe were thrown in the sea, It could be all the higher for mankind and each of the worse for that fishes".[27]: https://trentonvdkr41741.scrappingwiki.com/952344/arzneimittel_die_s%C3%A4ulen_moderner_medizin_und_gesundheit