Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts through the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have identified recurrent mutations in genes regulating tumor cell-microenvironment interaction... https://confuciusm666iba0.newsbloger.com/profile