If a mum or dad of the proband is thought to contain the pathogenic variant identified inside the proband, the danger to the sibs of inheriting the pathogenic variant is 50%. Thanks to decreased penetrance, sibs who inherit the pathogenic variant may or may not establish aHUS (see Penetrance). Modular https://industrial-boiler-rental75319.blogoscience.com/38388356/the-fact-about-ahu-s-that-no-one-is-suggesting